Table 5 WOMAC pain scores

Young et al

(110 patients)

[45]

Pain (Baseline)

12.2

12.3

Pain (3 months)

8.8

8.9

CS

Placebo

Mean, (SD), N

Mean, (SD), N

Paskins et al. (199 patients) [46]

Pain (Baseline)

10.7 ± 4.0, 66

10.7 ± 2.8, 66

Pain (2 months)

7.0 (4.3), 61

8.7 (4.1), 62

Pain (4 months)

7.9 (4.3), 59

9.1 (4.1), 59

Pain (6 months)

8.8 (4.3), 56

9.1 (4.1), 60

CS

Placebo

Lambert et al. (52 patients) [48]

Pain (Baseline)

310.1 ± 54.6 mm

314.3 ± 76.2

Pain (1 month)

149.6 ± 113 mm

276.4 ± 129.0

Pain (2 months)

157.4 ± 127.2 mm

306.5 ± 121.2

CS

Hyaluronic Acid

Spitzer et al. (312 patients) [52]

Pain (Baseline)

64.53 ± 0.98

63.40 ± 1.00

Pain (1 month)

35.04 ± 1.91

45.5 ± 1.97

Pain (6 months)

48.47 ± 2.47

44.03 ± 2.48

Group 0—CS

Group 1—CS + HA

Group 2—CS + HA

Group 3—CS + HA

De Rezende et al. (82 patients) [50]

Pain (Baseline)

11.1 (3.3)

10.4 (3.3)

10.5 (4.9)

10.5 (4.4)

Pain (1 months)

6.6 (5.4)

6.0 (3.9)

6.9 (5.2)

6.8 (4.4)

Pain (3 months)

7.1(4.2)

7.9 (3.3)

7.4 (4.4)

7.0 (5.0)

Pain (6 months)

6.9 (4.6)

8.0 (4.7)

6.4 (4.9)

7.9 (4.7)

Pain (12 months)

6.4 (4.1)

7.7 (4.8)

8.0 (5.2)

7.6 (4.7)