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Fig. 6 | BMC Musculoskeletal Disorders

Fig. 6

From: FHL2 deteriorates IL-1β induced inflammation, apoptosis, and extracellular matrix degradation in chondrocyte-like ATDC5 cells by mTOR and NF-ĸB pathways

Fig. 6

Knockdown of FHL2 exerts a multitude of beneficial effects through different mechanisms in IL-1β-induced chondrocyte-like ATDC5 cells. (A) Western blot analysis of p38, ERK1/2, JNK, and NF-ĸB p65 in the chondrocyte-like ATDC5 cells treated with and without IL-1β. (B) Western blot analysis of PI3K, AKT, and mTOR in the chondrocyte-like ATDC5 cells treated with and without IL-1β. The data are presented as the mean ± SD. Significant differences between groups were determined by Student’s t-test; * P < 0.05, ** P < 0.01, **** P < 0.0001; n = 3

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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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