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Fig. 8 | BMC Musculoskeletal Disorders

Fig. 8

From: The link between osteoporosis and frozen shoulder: exploring the therapeutic effect of TAK715 on reversing fibrosis and protecting against osteoporosis via the p38 MAPK signaling pathway

Fig. 8

the TAK715 could interpose the osteoclast activation and protect the osteoporosis. A The monocytes were successfully harvested from the rat bone marrow. B, C The osteoclasts were successfully induced by RANKL and the TAK715 could interpose the osteoclast activation at the concentration of 5 μM and the Alizarin red S(ARS) staining confirmed that TAK715 didn’t influence the bone formation ability at 5 μM. Scale Bar: 50 μm. D, E The FS side exhibit a local osteoporosis and more active osteoclasts both in control and OVX group and with the treatment of TAK715 the local osteoporosis in FS side could be corrected. Scale Bar: 200 μm. F, G The statistic results (n = 6) of Bone Volume/Total Volume, Trabecular number, Trabecular spacing, Trabecular thickness, Bone surface area/ Bone Volume and Number of Osteoclasts/ Bone Surface(/mm2) in Fig. 8 (D, E)

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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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